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Hydroxatone

Hydroxatone Anti-Aging BB (Beauty Balm) Cream, Universal Shade for ALL Skin Types, SPF 40 (BONUS Pack of 2, 1.5 ounce bottles) Hydroxatone Anti-Aging BB (Beauty Balm) Cream, Universal Shade for ALL Skin Types, SPF 40 (BONUS Pack of 2, 1.5 ounce bottles)
Sale Price: $30.25

Be Flawless. Be Youthful. Be Protected. Instantly conceals imperfections Long-term anti-aging results Broad Spectrum SPF 40 Sunscreen

Hydroxatone AM/PM Anti-Wrinkle Complex SPF 15, 1 Fl Oz Hydroxatone AM/PM Anti-Wrinkle Complex SPF 15, 1 Fl Oz
List Price: $69.00
Sale Price: $31.40

A multi functional anti aging powerhouse and moisturizer all in one. Our best selling age defying formula is clinically proven to soften the appearance of visible lines, wrinkles and crow's feet by helping the skin stimulate the production of collagen...

Hydroxatone Anti-Aging BB Cream Broad Spectrum SPF 40, Light 1.5oz Hydroxatone Anti-Aging BB Cream Broad Spectrum SPF 40, Light 1.5oz
List Price: $39.00
Sale Price: $29.99

"BB" stands for "Beauty Balm" a multi benefit perfecting cream that acts as an anti aging moisturizer, sunscreen and foundation all in one. Available in 3 skin flattering shades for multiple skin tones.

Beauty Must Haves

Kanebo Lunasol Water Cream Foundation 30g OC 01 Kanebo Lunasol Water Cream Foundation 30g OC 01
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Shiseido Tsubaki Golden Repair Conditioner

Shiseido Tsubaki Golden Repair Treatment with camellia amino - 200g
Shiseido Tsubaki Golden Repair Treatment with camellia amino - 200g
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Hydroxatone Anti-Aging BB (Beauty Balm) Cream, Universal Shade for ALL Skin Types, SPF 40 (BONUS Pack of 2, 1.5 ounce bottles) Hydroxatone Anti-Aging BB (Beauty Balm) Cream, Universal Shade for ALL Skin Types, SPF 40 (BONUS Pack of 2, 1.5 ounce bottles)
Sale Price: $30.25

Be Flawless. Be Youthful. Be Protected. Instantly conceals imperfections Long-term anti-aging results Broad Spectrum SPF 40 Sunscreen

Hydroxatone AM/PM Anti-Wrinkle Complex SPF 15, 1 Fl Oz Hydroxatone AM/PM Anti-Wrinkle Complex SPF 15, 1 Fl Oz
List Price: $69.00
Sale Price: $31.40

A multi functional anti aging powerhouse and moisturizer all in one. Our best selling age defying formula is clinically proven to soften the appearance of visible lines, wrinkles and crow's feet by helping the skin stimulate the production of collagen...

Hydroxatone Anti-Aging BB Cream Broad Spectrum SPF 40, Light 1.5oz Hydroxatone Anti-Aging BB Cream Broad Spectrum SPF 40, Light 1.5oz
List Price: $39.00
Sale Price: $29.99

"BB" stands for "Beauty Balm" a multi benefit perfecting cream that acts as an anti aging moisturizer, sunscreen and foundation all in one. Available in 3 skin flattering shades for multiple skin tones.

Hydroxatone Hydrolyze Intensive Under Eye Treatment, Net Wt. 0.5 Oz. Hydroxatone Hydrolyze Intensive Under Eye Treatment, Net Wt. 0.5 Oz.
List Price: $69.00
Sale Price: $31.99

A lightweight, intensive anti aging eye treatment that addresses the visible signs of aging around the eyes: dark circles, under eye bags, puffiness, crow's feet and deep lines. Clinically proven to start improving the appearance of crow's feet, lines and wrinkles within 2 weeks and reduce dark circles by 31% in 8 weeks.

Hydroxatone Anti-Aging BB Cream with Broad Spectrum, Universal Tone, SPF40 1.5 oz, Pack of 2 Hydroxatone Anti-Aging BB Cream with Broad Spectrum, Universal Tone, SPF40 1.5 oz, Pack of 2
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Hydroxatone Anti-Aging BB Cream with Broad Spectrum, Universal Tone, SPF40 1.5 oz, Pack of 2

Hydroxatone Anti-Aging BB Cream - 1.5 oz (Light) Hydroxatone Anti-Aging BB Cream - 1.5 oz (Light)
Sale Price: $34.79

Hydroxatone Anti-Aging BB Cream (All Skin Types) with SPF 40 is an all-in-one multi-tasking perfecting cream that hydrates, conceals, protects, reduces the look of aging, and brightens skin in just one step...

Hydroxatone Intensive Overnight Repair Cream, 1 oz. Hydroxatone Intensive Overnight Repair Cream, 1 oz.
List Price: $59.00
Sale Price: $31.99

A luxurious anti aging night treatment designed to optimize the skin's overnight repair process to improve the skin's resilience, elasticity, texture, radiance, volume, and contour for a younger looking complexion.

Hydroxatone Instant Wrinkle Filler 1. oz (Full Size) NEW & SEALED Hydroxatone Instant Wrinkle Filler 1. oz (Full Size) NEW & SEALED
List Price: $79.99
Sale Price: $27.95

Instantly improves the appearance of fine lines and wrinkles Perfect quick fix to the wrinkle situation Instantly covers the look of imperfections for a flawless, gorgeous complexion

Hydroxatone Liftalyze Eye-lifting Serum 0.17fl.oz/5ml for Firmer Looking Eyes Hydroxatone Liftalyze Eye-lifting Serum 0.17fl.oz/5ml for Firmer Looking Eyes
Sale Price: $19.99

Restore the appearance of youth along with the delicate skin around the eye area. The ingredients in this lightweight serum help make skin around the eyes appear tighter and firmer looking-while providing intense moisture...

Hydroxatone Ultimate Essentials Kit, 9.85 Ounce Hydroxatone Ultimate Essentials Kit, 9.85 Ounce
List Price: $49.00
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Hydroxatone Ultimate Essentials Kit contains 4 Anti-Aging Must-Haves at a $130.00 value!

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Hydroxatone Anti-Acne CC Cream Medium (NEW) RETAIL VALUE $59.95
Hydroxatone Anti-Acne CC Cream Medium (NEW) RETAIL VALUE $59.95

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Hydroxatone Anti-Aging BB Cream SPF 40 All Skin Type 1.5 oz (Universal Tone)
Hydroxatone Anti-Aging BB Cream SPF 40 All Skin Type 1.5 oz (Universal Tone)

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HYDROXATONE AM/PM ANTI WRINKLE COMPLEX SPF 15 1 oz New In Box Sunscreen
HYDROXATONE AM/PM ANTI WRINKLE COMPLEX SPF 15 1 oz New In Box Sunscreen

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Hydroxatone Deep Wrinkle Concentrate Targeted Serum 0.25oz/7.5ml  New In Box
Hydroxatone Deep Wrinkle Concentrate Targeted Serum 0.25oz/7.5ml New In Box

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Declatone Neck and Chest Complex 0.5oz/14.79 g By Hydraxonate New In Box
Declatone Neck and Chest Complex 0.5oz/14.79 g By Hydraxonate New In Box

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New Sealed Hydroxatone Revitalizing Microdermabrasion Facial Scrub Exfoliant 1oz
New Sealed Hydroxatone Revitalizing Microdermabrasion Facial Scrub Exfoliant 1oz

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Hydroxatone Instant Lift Pads Concentrated Anti Wrinkle Results 60 Count, BNIB
Hydroxatone Instant Lift Pads Concentrated Anti Wrinkle Results 60 Count, BNIB

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Duo Hydroxatone Intensive Youth Serum  ( NEW ) RETAIL PRICE $89.95 per item
Duo Hydroxatone Intensive Youth Serum ( NEW ) RETAIL PRICE $89.95 per item

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Lot of 2 Sealed CELTRIXA Lotion by Hydroxatone (2 x 3oz) 6oz Total FREE SHIPPING
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HYDROXATONE Intensive Youth Serum Age-Defying Formula Travel Size 0.2 oz SEALED
HYDROXATONE Intensive Youth Serum Age-Defying Formula Travel Size 0.2 oz SEALED

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Hydroxatone Revitalizing Microdermabrasion (1.7 ozs ) - New/Seal/No Box
Hydroxatone Revitalizing Microdermabrasion (1.7 ozs ) - New/Seal/No Box

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Hydroxatone Declatone Neck & Decollete Complex ( 0.5 oz ) - New/Seal
Hydroxatone Declatone Neck & Decollete Complex ( 0.5 oz ) - New/Seal

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Lot of 2 CELTRIXA Lotion by Hydroxatone (2 x 3oz) 6oz
Lot of 2 CELTRIXA Lotion by Hydroxatone (2 x 3oz) 6oz

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HYDROXATONE 6 PIECES- INSTANT EFFECT, INTNSIVE EYE TRTMNT, AM PM ANTIWRINKLE
HYDROXATONE 6 PIECES- INSTANT EFFECT, INTNSIVE EYE TRTMNT, AM PM ANTIWRINKLE

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LOT OF 50 Hydroxatone Celtrixa Stretch Mark Reducer Lotion 3 fl oz (88 ml) New
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Hydroxatone Celtrixa Stretch Mark Lotion 3 Fl Oz (88 Ml)
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New Celtrixa Stretch Mark Lotion Moisturizer Reduces Appearance 4 fl oz 118 ml
New Celtrixa Stretch Mark Lotion Moisturizer Reduces Appearance 4 fl oz 118 ml

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Hydroxatone Revitalizing Microdermabrasion (NEW UNSEALED) 0.5oz great try me sz
Hydroxatone Revitalizing Microdermabrasion (NEW UNSEALED) 0.5oz great try me sz

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Hydroxatone Intensive Youth Serum ( NEW ) RETAIL PRICE $89.95
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Hydroxatone Anti-Aging BB Cream Broad Spectrum SPF 40, Medium
Hydroxatone Anti-Aging BB Cream Broad Spectrum SPF 40, Medium

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Hydroxatone Celtrixa Stretch Mark Lotion 3 fl oz (88 ml)
Hydroxatone Celtrixa Stretch Mark Lotion 3 fl oz (88 ml)

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1x Hydroxatone Celtrixa Stretch Mark Lotion 3oz FREE WORLDWIDE SHIPPING!
1x Hydroxatone Celtrixa Stretch Mark Lotion 3oz FREE WORLDWIDE SHIPPING!

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LOT OF 2 Hydroxatone Celtrixa Stretch Mark Lotion 3oz Free Worldwide Shipping
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LOT OF 4 Hydroxatone Celtrixa Stretch Mark Lotion 3oz Free Worldwide Shipping
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New! Hydroxatone Cleanser, Age-Defying Toner & Microdermabrasion w/Gft Bag!
New! Hydroxatone Cleanser, Age-Defying Toner & Microdermabrasion w/Gft Bag!

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   1

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How to Overcome the Appearance of Wrinkles

DNA plays critical role in rejuvenating aging skin.
by Verretta Deorosan, M.D.

A graduate of UCLA School of Medicine, Dr. Verretta Deorosan is board certified by the American Board of Internal Medicine. She is a primary care physician with two practices in Los Angeles, California. Her emphasis is on adult and geriatric medicine with a broad-spectrum alternative/complementary approach.

A new understanding of what causes skin aging, plus the development of substances that inhibit or mitigate premature skin aging, can result in profound changes in the appearance of mature skin.

Aging gives and takes away: It gives our skin unwanted free radical damage, and it takes away healthy collagen, making skin stiff and inflexible and causing wrinkled, dried-out skin. But now, researchers can offer new ingredients to help change this look. One of the most promising of these "cosmeceutical" ingredients is called Matrixyl®. Indeed, the results of early research on its stunning effects on wrinkled skin caused a stir at the 20th World Congress of Dermatology in Paris (Matrixyl® 1999).

Significant, Progressive Changes

A six-month study revealed that Matrixyl® temporarily produces "a highly significant reduction in the deep and moderate wrinkles," the researchers determined. In fact, they documented changes as high as 68% (Matrixyl® 1999). The research left no doubt: Women who had used Matrixyl® throughout the study experienced dramatic results. Plus the longer they used it, the better they looked.

Matrixyl® came into being through the work of two branches of dermatological research: the search for substances that accelerate recovery from skin wounds and investigations into what causes wrinkles. When skin is wounded, tiny cells called fibroblasts change their characteristics (kind of like changing into their work clothes) and help to repair the damaged tissue and assist in the process of forming new tissue. Part of their job is to manufacture new collagen, an important component of connective tissue.

Fibroblasts never completely lose this ability to create more collagen, even in mature skin. After all, even older people’s wounds heal eventually. But as you grow older, your collagen levels dwindle, and your taut, dewy skin dries out and crinkles. "Wrinkles are nothing more or less than the depletion of collagen in the skin," according to Robert Garonne, Professor of Cell Biology at Lyon University in France.

Acting Like Old Tissue

Why do skin fibroblasts slow down their collagen production as we get older, even though they can still produce it? Scientists found out why: Fibroblasts in aged tissue start acting old themselves. But and this is a big but when they are isolated from aged tissue in the lab and exposed to the same stimulating factors the body uses to kick them into gear, skin fibroblasts once again start producing significant quantities of collagen (Matrixyl® 1999).

With this knowledge, cosmetic scientists started exploring ways to stimulate fibroblasts in living skin on living people, not just in Petri dishes in the laboratory. Using the most advanced cosmetic technology, they developed a five-sided molecule called palmitoyl pentapeptide. This molecular "suitcase" is small enough to be absorbed into skin tissue and uses a delivery system that specifically targets skin cells providing door-to-door delivery, as it were. The pentapeptide was then loaded with a precious cargo for skin cells: the stimulating factors that get fibroblasts pumping out collagen, plus a unique agent called Endonucleine™ (Laboratoires Serobiologiques 1989).

Skin Needs Hydration

Skin needs water a great deal of it to keep its cells plump and saturated with moisture. These moisture-saturated skin cells help your skin look firm and taut. As aging skin dries out and loses its ability to stay hydrated, your skin turns from looking like peaches to prunes.

Endonucleine™ helps skin maintain its hydrating ability by supplying natural and synthetic versions of skin cells’ own genetic material: the nucleic acids DNA and RNA. DNA carries the specific information for the cell, including how to hydrate it, while RNA transmits that information. By reconstituting the skin’s DNA and RNA, Endonucleine™ has a pronounced hydrating and moisturizing effect on the skin.

A Classic Double-Blind Study

Matrixyl® wowed dermatologists at the Paris conference with its demonstrated effects in women. The six-month, double-blind study involved 35 women ages 34 to 72, all of whom had wrinkles (skin experts call it "photodamaged skin"). The researchers set five parameters: global area of wrinkles, density of furrows, volume of wrinkles, mean depth of the main wrinkle, and roughness of skin. Using sophisticated imaging techniques, including photometry and computerized image analysis, they measured these five markers at the beginning of the study and two months, four months, and six months later.

The women were divided into two groups. The first group of 25 women put a cream containing Matrixyl® on one side of the face and a placebo cream on the other. The other 10 put Matrixyl® cream on one side and a commercial vitamin-C cream on the other. None of the women knew which cream contained what.

The researchers reported, "A highly significant reduction in the deep and moderate wrinkles was obtained on the side treated with 3% Matrixyl®. This reduction increased with time, and a difference developed from the placebo, which never produced a significant effect. The surface area occupied by deep wrinkles was reduced by a mean of 68% over six months. The surface area occupied by moderate wrinkles was reduced by a mean of 51% over six months."

Regarding the density of furrows, the researchers reported, "This parameter takes into account the length of the deepest wrinkles; their total sum relative to the area under analysis is used to define the density per unit area. A very marked reduction in the mean density was found for Matrixyl®, whereas the placebo tended to have the opposite effect. The results produced by Matrixyl® improved with time: -28% after two months, -31% after four months, and -47% after six months."

Big Changes

The researchers also assessed the volume of wrinkles. To do this, for each subject they selected one of the deepest wrinkles, then measured its changes over time. As to their results, they reported that the volume of the wrinkle "decreased with time, successively being reduced by 7% (two months), 21% (four months), and 24% (six months). The placebo continued to produce no effect."

Matrixyl® also helped to reduce the roughness of the skin, an effect that became visible after two months (-10%), which intensified with time to reach -16% after six months."

Concerning the depth of the main wrinkle, they reported, "This determination is useful because it provides a good illustration of the improvement obtained on the most severely affected area of skin. It is therefore a rigorous criterion for evaluating the efficacy of the product. The mean depth of the wrinkle decreased throughout the treatment."

Self-Evaluation of Female Subjects

The women reported that Matrixyl® "produces lasting moisturizing of the skin," "makes the skin smoother," "makes the skin more supple," and "reduces wrinkles and lines." These and their own results led the researchers to conclude that their study demonstrates "the long-term anti-wrinkle activity of Matrixyl®. The parameters used to compare the Matrixyl® cream with the placebo cream were significant throughout the treatment. These differences increased with time, which indicates that the physiological activity of the peptide in the skin was progressive."

There you have it. We now have a golden opportunity to look as good as we feeland for far longer. After all, many of us have reached another one of those irritating milestones: The clerk no longer asks to see your ID when you buy that bottle of wine. He doesn’t see how young at heart you are. All he sees are the years on your face.

"Don’t deny your age. Defy it!" actress Melanie Griffith urges in a popular TV ad. With Matrixyl® you can defy the premature signs of aging, by reminding your skin cells what they’re supposed to do: stay hydrated and produce collagen. It just took 21st-century technology to figure out how to do it, and now we all can reap the benefits. I can hardly wait to tell my patients.


 

 

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Tagged : Anti-Aging Wrinkle Cream, MATRIXYL, MATRIXYL history, egg

3 Responses

  1. Sheila Says:
    Jan 10th, 2010 at 8:08 am

    MATRIXYL are great!

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Olay Regenerist Micro-Sculpting Cream, 1.7 Ounce Olay Regenerist Micro-Sculpting Cream, 1.7 Ounce

The result of over 50 years of Olay research, this luxurious cream has the highest concentration of our signature amino-peptide complex infused with intracellular fortifier and a touch of precious marine proteins...

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